The Doctor C. C. and Mabel L. Criss Health Sciences Complex provides health science classrooms, multipurpose laboratory spaces, and seminar rooms and is the main facility for the research activities of the faculty of the School of Medicine. In addition, the Criss Health Sciences Complex accommodates the administrative support area for the School of Pharmacy and Health Professions as well as lounge and meeting space dedicated to the students. The administrative offices of the School of Medicine and School of Nursing are also located in the Criss Health Sciences Complex. 

The Hixson-Lied Science Building is connected to Criss Health Sciences Complex and provides expansion space for functions of the health sciences programs. The Hixson Lied Science Building is comprised of heath science classrooms, undergraduate science departments, and administration and faculty offices of the School of Pharmacy and Health Professions.

The CHI Health Creighton University Medical Center Bergan Mercy was established in 2017 and is a place where patients are at the heart of our patient-focused care. The campus is designed to heal the body, mind, and spirit of every person in a more comfortable, less stressful hospital environment. A full range of medical services include heart and vascular care, emergency services, surgery, maternity, cancer care, and diagnostic imaging. The facility serves as the major affiliated teaching hospital for the Creighton University School of Medicine, School of Pharmacy and Health Professions, and College of Nursing. 

The CHI Health Creighton University Medical Center University Campus is a new, 80,000 square foot community health center that serves the health care needs of the downtown and northeast Omaha communities. Planned and designed in collaboration with the neighborhoods the facility will serve, a full complement of health professionals are ready to care for patient needs. Care teams work together to provide the right kind of care, and the center serves as a model for Creighton University's inter-professional education for heath care program. 

The Dr. Harry H. & Maude Boyne Building is a 150,000 square foot facility that houses the Creighton University School of Dentistry as well as the School of Pharmacy and Health Professions Occupational and Physical Therapy programs. The first floor consists of student services, classrooms, Physical Therapy/Occupational Therapy administrative offices, clinics and research laboratories. The adult dental clinic and dental departmental faculty offices occupy the second level. The third level is occupied by the children’s dental clinic, basic and dental science laboratories, research spaces, seminar rooms and dental administrative offices.

The Creighton Bio-Information Center (BIC) brings to the health sciences campus a focal point for modern and innovative learning and research.  The services provided are available to all distance and campus students, affiliated faculty and staff, and are a resource for the Creighton medical community. The Health Sciences Library is housed in the Bio-Information Center and includes the School of Pharmacy and Health Professions’ Center for Drug Information and Evidence-Based Practice and Center for Medication Therapy Management.  These centers serve as training sites for students in the Doctor of Pharmacy program. In addition, the BIC contains dedicated classroom space for students in the Occupational Therapy, Physical Therapy and Pharmacy programs.